Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

W Yang; BH Wang; I Wang; L Huang; F Savira; A Kompa; BM Jucker; RN Willette; D Kelly; H Krum; Z Li; Q Fu

Journal article

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

W Yang, BH Wang, I Wang, L Huang, F Savira, A Kompa, BM Jucker, RN Willette, D Kelly, H Krum, Z Li, Q Fu

Heart Lung and Circulation | ELSEVIER SCIENCE INC | Published : 2019

DOI: 10.1016/j.hlc.2017.12.001

Abstract

Background: Cardiac remodelling is a dynamic process whereby structural and functional changes occur within the heart in response to injury or inflammation. Recent studies have demonstrated reactive oxygen species sensitive MAPK, apoptosis signal-regulating kinase 1 (ASK1) plays a critical role in cardiac remodelling. This study aims to determine the effectiveness of small molecule ASK1 inhibitors on these processes and their therapeutic potential. Methods: Neonatal rat cardiac fibroblasts (NCF) were pre-treated with ASK1 inhibitors, G2261818A (G226) and G2358939A (G235), for 2 hours before stimulated with 100 nM angiotensin II (AngII), 10 μM indoxyl sulphate (IS) or 10 ng/ml transforming gr..

View full abstract

University of Melbourne Researchers

Andrew Kompa Author

Darren Kelly Author

Related Projects (3)

MECHANISMS UNDERLYING THE CONTRIBUTION OF UREMIC TOXINS TO CARDIORENAL SYNDROME

Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one ..

PREVENTION AND TREATMENT OF CHRONIC HEART AND KIDNEY DISEASE VIA EPIDEMIOLOGICAL, PHARMACOLOGICAL DEVICE AND CELL-BASED APPROACHES

Heart failure describes where the heart cannot pump adequately to meet the needs of the body. This condition has a high mortality despite re..

NOVEL APPROACHES TO THE PREVENTION AND TREATMENT OF CHRONIC HEART DISEASE AND ITS CO-MORBID COMPLICATIONS

Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly a..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by National Health and Medical Research Council of Australia (Program Grants 546272 and 1092642 and Project Grant 1087355).